Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1261950..1262751 Replicon chromosome
Accession NC_017631
Organism Escherichia coli ABU 83972

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag ECABU_RS06245 Protein ID WP_000854739.1
Coordinates 1262371..1262751 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag ECABU_RS06240 Protein ID WP_001285482.1
Coordinates 1261950..1262324 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECABU_RS06205 1258038..1258493 + 456 WP_000581502.1 hypothetical protein -
ECABU_RS28985 1258612..1258823 - 212 Protein_1174 hypothetical protein -
ECABU_RS06215 1258904..1259725 + 822 WP_001234710.1 DUF945 domain-containing protein -
ECABU_RS06220 1259988..1260461 + 474 WP_000855076.1 antirestriction protein -
ECABU_RS06225 1260477..1260953 + 477 WP_001186170.1 RadC family protein -
ECABU_RS06230 1261016..1261237 + 222 WP_000692315.1 DUF987 domain-containing protein -
ECABU_RS06235 1261256..1261900 + 645 WP_000086763.1 hypothetical protein -
ECABU_RS06240 1261950..1262324 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECABU_RS06245 1262371..1262751 + 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
ECABU_RS06250 1262748..1263236 + 489 WP_001054232.1 hypothetical protein -
ECABU_RS06255 1263256..1263453 + 198 WP_000772027.1 DUF957 domain-containing protein -
ECABU_RS06260 1263538..1264365 + 828 WP_001304477.1 DUF4942 domain-containing protein -
ECABU_RS06270 1264852..1265790 + 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
ECABU_RS06275 1265845..1266582 + 738 WP_000283664.1 zinc-binding phosphatase -
ECABU_RS06280 1266606..1267160 + 555 WP_001001909.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T27256 WP_000854739.1 NC_017631:1262371-1262751 [Escherichia coli ABU 83972]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T27256 NC_017631:1262371-1262751 [Escherichia coli ABU 83972]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT27256 WP_001285482.1 NC_017631:1261950-1262324 [Escherichia coli ABU 83972]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT27256 NC_017631:1261950-1262324 [Escherichia coli ABU 83972]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References