Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 1802604..1803101 Replicon chromosome
Accession NZ_CP117962
Organism Escherichia coli strain JM109

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PT299_RS10055 Protein ID WP_001173343.1
Coordinates 1802604..1802777 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag PT299_RS10060 Protein ID WP_000398619.1
Coordinates 1802805..1803101 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT299_RS10045 (1799274) 1799274..1800731 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
PT299_RS10050 (1800968) 1800968..1802485 + 1518 WP_001295074.1 lysine--tRNA ligase -
PT299_RS10055 (1802604) 1802604..1802777 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PT299_RS10060 (1802805) 1802805..1803101 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PT299_RS10065 (1803328) 1803328..1803600 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
PT299_RS10070 (1803612) 1803612..1803842 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
PT299_RS10075 (1804023) 1804023..1805654 + 1632 WP_001216456.1 sensor histidine kinase -
PT299_RS10080 (1805651) 1805651..1806370 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T272550 WP_001173343.1 NZ_CP117962:c1802777-1802604 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT272550 WP_000398619.1 NZ_CP117962:c1803101-1802805 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References