Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 563748..564366 Replicon chromosome
Accession NC_017631
Organism Escherichia coli ABU 83972

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ECABU_RS02700 Protein ID WP_001291435.1
Coordinates 563748..563966 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ECABU_RS02705 Protein ID WP_000344800.1
Coordinates 563992..564366 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECABU_RS02670 559036..559608 + 573 WP_000779831.1 YbaY family lipoprotein -
ECABU_RS02675 559639..559950 - 312 WP_000409908.1 MGMT family protein -
ECABU_RS02680 560329..560682 + 354 WP_000878140.1 DUF1428 domain-containing protein -
ECABU_RS02685 560724..562274 - 1551 WP_001528761.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ECABU_RS02690 562438..562908 - 471 WP_001304825.1 YlaC family protein -
ECABU_RS02695 563024..563575 - 552 WP_000102539.1 maltose O-acetyltransferase -
ECABU_RS02700 563748..563966 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
ECABU_RS02705 563992..564366 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ECABU_RS02710 564911..568060 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
ECABU_RS02715 568083..569276 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T27255 WP_001291435.1 NC_017631:c563966-563748 [Escherichia coli ABU 83972]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T27255 NC_017631:c563966-563748 [Escherichia coli ABU 83972]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT27255 WP_000344800.1 NC_017631:c564366-563992 [Escherichia coli ABU 83972]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT27255 NC_017631:c564366-563992 [Escherichia coli ABU 83972]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References