Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1705867..1706462 Replicon chromosome
Accession NZ_CP117962
Organism Escherichia coli strain JM109

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag PT299_RS09555 Protein ID WP_000239577.1
Coordinates 1705867..1706217 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag PT299_RS09560 Protein ID WP_001223208.1
Coordinates 1706211..1706462 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT299_RS09535 (1701313) 1701313..1702335 - 1023 WP_001313531.1 ABC transporter permease -
PT299_RS09540 (1702349) 1702349..1703851 - 1503 WP_000205825.1 sugar ABC transporter ATP-binding protein -
PT299_RS09545 (1703991) 1703991..1704947 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
PT299_RS09550 (1705257) 1705257..1705787 + 531 WP_000055075.1 inorganic diphosphatase -
PT299_RS09555 (1705867) 1705867..1706217 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
PT299_RS09560 (1706211) 1706211..1706462 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
PT299_RS09565 (1706674) 1706674..1707015 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
PT299_RS09570 (1707018) 1707018..1710797 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T272549 WP_000239577.1 NZ_CP117962:c1706217-1705867 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT272549 WP_001223208.1 NZ_CP117962:c1706462-1706211 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References