Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 1620856..1621670 Replicon chromosome
Accession NZ_CP117962
Organism Escherichia coli strain JM109

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag PT299_RS09120 Protein ID WP_001054376.1
Coordinates 1620856..1621113 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag PT299_RS09125 Protein ID WP_001309181.1
Coordinates 1621125..1621670 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT299_RS09095 (1616144) 1616144..1617250 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
PT299_RS09100 (1617315) 1617315..1618295 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
PT299_RS09105 (1618405) 1618405..1618610 + 206 Protein_1543 HNH endonuclease -
PT299_RS09110 (1618878) 1618878..1620118 - 1241 Protein_1544 helicase YjhR -
PT299_RS09115 (1620234) 1620234..1620365 + 132 WP_001309182.1 hypothetical protein -
PT299_RS09120 (1620856) 1620856..1621113 + 258 WP_001054376.1 YjhX family toxin Toxin
PT299_RS09125 (1621125) 1621125..1621670 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
PT299_RS09130 (1621726) 1621726..1622472 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
PT299_RS09135 (1622641) 1622641..1622859 + 219 Protein_1549 hypothetical protein -
PT299_RS09140 (1622897) 1622897..1623013 + 117 Protein_1550 VOC family protein -
PT299_RS09145 (1623258) 1623258..1624379 + 1122 WP_000010829.1 M42 family metallopeptidase -
PT299_RS09150 (1624376) 1624376..1624654 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
PT299_RS09155 (1624666) 1624666..1625979 + 1314 WP_000460842.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 1609870..1629894 20024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T272548 WP_001054376.1 NZ_CP117962:1620856-1621113 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT272548 WP_001309181.1 NZ_CP117962:1621125-1621670 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References