272544

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1153326..1153944 Replicon chromosome
Accession NZ_CP117962
Organism Escherichia coli strain JM109

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag PT299_RS06885 Protein ID WP_001290581.1
Coordinates 1153726..1153944 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PT299_RS06880 Protein ID WP_000344800.1
Coordinates 1153326..1153700 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT299_RS06870 (1148415) 1148415..1149608 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PT299_RS06875 (1149631) 1149631..1152780 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PT299_RS06880 (1153326) 1153326..1153700 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PT299_RS06885 (1153726) 1153726..1153944 + 219 WP_001290581.1 HHA domain-containing protein Toxin
PT299_RS06890 (1154116) 1154116..1154667 + 552 WP_000102564.1 maltose O-acetyltransferase -
PT299_RS06895 (1154783) 1154783..1155253 + 471 WP_000136192.1 YlaC family protein -
PT299_RS06900 (1155417) 1155417..1156967 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PT299_RS06905 (1157009) 1157009..1157362 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PT299_RS06915 (1157741) 1157741..1158052 + 312 WP_000409911.1 MGMT family protein -
PT299_RS06920 (1158083) 1158083..1158655 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T272544 WP_001290581.1 NZ_CP117962:1153726-1153944 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT272544 WP_000344800.1 NZ_CP117962:1153326-1153700 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References