Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 149492..150130 Replicon chromosome
Accession NZ_CP117962
Organism Escherichia coli strain JM109

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PT299_RS02000 Protein ID WP_000813794.1
Coordinates 149954..150130 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PT299_RS01995 Protein ID WP_001270286.1
Coordinates 149492..149908 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT299_RS01975 (144644) 144644..145585 - 942 WP_001251304.1 ABC transporter permease -
PT299_RS01980 (145586) 145586..146599 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
PT299_RS01985 (146617) 146617..147762 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
PT299_RS01990 (148007) 148007..149413 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
PT299_RS01995 (149492) 149492..149908 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PT299_RS02000 (149954) 149954..150130 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PT299_RS02005 (150352) 150352..150582 + 231 WP_000494244.1 YncJ family protein -
PT299_RS02010 (150674) 150674..152635 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PT299_RS02015 (152708) 152708..153244 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PT299_RS02020 (153336) 153336..154511 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T272543 WP_000813794.1 NZ_CP117962:c150130-149954 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT272543 WP_001270286.1 NZ_CP117962:c149908-149492 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References