Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3536732..3537386 Replicon chromosome
Accession NZ_CP117960
Organism Escherichia coli strain B-3008

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag PT288_RS17205 Protein ID WP_000244777.1
Coordinates 3536979..3537386 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PT288_RS17200 Protein ID WP_000354046.1
Coordinates 3536732..3536998 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT288_RS17175 (3531901) 3531901..3532644 + 744 WP_000951964.1 SDR family oxidoreductase -
PT288_RS17180 (3532701) 3532701..3534134 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
PT288_RS17185 (3534179) 3534179..3534490 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PT288_RS17190 (3534654) 3534654..3535313 + 660 WP_000250274.1 hemolysin III family protein -
PT288_RS17195 (3535509) 3535509..3536489 - 981 WP_000886083.1 tRNA-modifying protein YgfZ -
PT288_RS17200 (3536732) 3536732..3536998 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PT288_RS17205 (3536979) 3536979..3537386 + 408 WP_000244777.1 protein YgfX Toxin
PT288_RS17210 (3537426) 3537426..3537947 - 522 WP_001055874.1 flavodoxin FldB -
PT288_RS17215 (3538059) 3538059..3538955 + 897 WP_000806628.1 site-specific tyrosine recombinase XerD -
PT288_RS17220 (3538980) 3538980..3539690 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PT288_RS17225 (3539696) 3539696..3541429 + 1734 WP_000813201.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T272527 WP_000244777.1 NZ_CP117960:3536979-3537386 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT272527 WP_000354046.1 NZ_CP117960:3536732-3536998 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References