Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1385864..1386482 Replicon chromosome
Accession NZ_CP117960
Organism Escherichia coli strain B-3008

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PT288_RS06875 Protein ID WP_001291435.1
Coordinates 1386264..1386482 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PT288_RS06870 Protein ID WP_000344800.1
Coordinates 1385864..1386238 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT288_RS06860 (1380953) 1380953..1382146 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PT288_RS06865 (1382169) 1382169..1385318 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PT288_RS06870 (1385864) 1385864..1386238 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PT288_RS06875 (1386264) 1386264..1386482 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PT288_RS06880 (1386654) 1386654..1387205 + 552 WP_000102564.1 maltose O-acetyltransferase -
PT288_RS06885 (1387321) 1387321..1387791 + 471 WP_000136192.1 YlaC family protein -
PT288_RS06890 (1387955) 1387955..1389505 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PT288_RS06895 (1389547) 1389547..1389900 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PT288_RS06905 (1390279) 1390279..1390590 + 312 WP_000409911.1 MGMT family protein -
PT288_RS06910 (1390621) 1390621..1391193 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T272518 WP_001291435.1 NZ_CP117960:1386264-1386482 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT272518 WP_000344800.1 NZ_CP117960:1385864-1386238 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References