Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 994608..995313 Replicon chromosome
Accession NZ_CP117960
Organism Escherichia coli strain B-3008

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag PT288_RS04970 Protein ID WP_000539521.1
Coordinates 994608..994994 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PT288_RS04975 Protein ID WP_001280945.1
Coordinates 994984..995313 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT288_RS04950 (990612) 990612..991238 + 627 WP_001295292.1 glutathione S-transferase GstB -
PT288_RS04955 (991235) 991235..992350 - 1116 WP_000555031.1 aldose sugar dehydrogenase YliI -
PT288_RS04960 (992461) 992461..992844 - 384 WP_000497137.1 biofilm formation regulator BssR -
PT288_RS04965 (993057) 993057..994382 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
PT288_RS04970 (994608) 994608..994994 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PT288_RS04975 (994984) 994984..995313 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
PT288_RS04980 (995383) 995383..996711 - 1329 WP_000086877.1 GGDEF domain-containing protein -
PT288_RS04985 (996719) 996719..999067 - 2349 WP_012304894.1 EAL domain-containing protein -
PT288_RS04990 (999245) 999245..1000156 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T272517 WP_000539521.1 NZ_CP117960:994608-994994 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT272517 WP_001280945.1 NZ_CP117960:994984-995313 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References