Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 366430..367068 Replicon chromosome
Accession NZ_CP117960
Organism Escherichia coli strain B-3008

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PT288_RS01840 Protein ID WP_000813794.1
Coordinates 366892..367068 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PT288_RS01835 Protein ID WP_001270286.1
Coordinates 366430..366846 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT288_RS01815 (361582) 361582..362523 - 942 WP_001251313.1 ABC transporter permease -
PT288_RS01820 (362524) 362524..363537 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
PT288_RS01825 (363555) 363555..364700 - 1146 WP_000047426.1 ABC transporter substrate-binding protein -
PT288_RS01830 (364945) 364945..366351 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
PT288_RS01835 (366430) 366430..366846 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PT288_RS01840 (366892) 366892..367068 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PT288_RS01845 (367290) 367290..367520 + 231 WP_000494244.1 YncJ family protein -
PT288_RS01850 (367612) 367612..369573 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PT288_RS01855 (369646) 369646..370182 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PT288_RS01860 (370274) 370274..371449 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T272516 WP_000813794.1 NZ_CP117960:c367068-366892 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT272516 WP_001270286.1 NZ_CP117960:c366846-366430 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References