272514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 201945..202471 Replicon chromosome
Accession NZ_CP117960
Organism Escherichia coli strain B-3008

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag PT288_RS01030 Protein ID WP_000323025.1
Coordinates 202184..202471 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag PT288_RS01025 Protein ID WP_000534858.1
Coordinates 201945..202184 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT288_RS00995 (197282) 197282..197771 + 490 Protein_195 class I SAM-dependent methyltransferase -
PT288_RS01000 (198249) 198249..198670 + 422 Protein_196 hypothetical protein -
PT288_RS01005 (199326) 199326..200348 + 1023 Protein_197 ISNCY family transposase -
PT288_RS01010 (200469) 200469..200618 + 150 WP_011443592.1 protein YdfW -
PT288_RS01015 (201080) 201080..201412 - 333 WP_001301033.1 FlxA-like family protein -
PT288_RS01020 (201615) 201615..201920 - 306 WP_001326990.1 protein YdfV -
PT288_RS01025 (201945) 201945..202184 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PT288_RS01030 (202184) 202184..202471 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PT288_RS01035 (202543) 202543..202698 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
PT288_RS01040 (202915) 202915..203166 + 252 WP_000980994.1 protein Rem -
PT288_RS01045 (203233) 203233..203511 + 279 WP_012304870.1 hypothetical protein -
PT288_RS01050 (203513) 203513..204562 + 1050 WP_001265198.1 DUF968 domain-containing protein -
PT288_RS01055 (204576) 204576..205328 + 753 WP_001047134.1 antitermination protein -
PT288_RS01060 (205606) 205606..205695 - 90 WP_120795389.1 hypothetical protein -
PT288_RS01065 (205750) 205750..205962 - 213 WP_000087756.1 cold shock-like protein CspF -
PT288_RS01070 (206263) 206263..206478 + 216 WP_000066484.1 cold shock-like protein CspB -
PT288_RS01075 (206842) 206842..207012 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
PT288_RS01080 (207232) 207232..207447 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 177042..239666 62624
- inside Prophage - - 171913..254077 82164


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T272514 WP_000323025.1 NZ_CP117960:202184-202471 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT272514 WP_000534858.1 NZ_CP117960:201945-202184 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References