Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4641844..4642676 Replicon chromosome
Accession NZ_CP117959
Organism Escherichia coli strain B-2207

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag PT284_RS23250 Protein ID WP_000854765.1
Coordinates 4642302..4642676 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag PT284_RS23245 Protein ID WP_001540478.1
Coordinates 4641844..4642212 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT284_RS23215 (4638962) 4638962..4639157 + 196 Protein_4385 DUF905 family protein -
PT284_RS23220 (4639275) 4639275..4640093 + 819 WP_274270998.1 DUF932 domain-containing protein -
PT284_RS23225 (4640093) 4640093..4640266 + 174 WP_001183321.1 hypothetical protein -
PT284_RS23230 (4640432) 4640432..4640905 + 474 WP_021532903.1 antirestriction protein -
PT284_RS23235 (4640921) 4640921..4641397 + 477 WP_001186786.1 RadC family protein -
PT284_RS23240 (4641460) 4641460..4641681 + 222 WP_021532904.1 DUF987 domain-containing protein -
PT284_RS23245 (4641844) 4641844..4642212 + 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PT284_RS23250 (4642302) 4642302..4642676 + 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
PT284_RS23255 (4642673) 4642673..4643164 + 492 WP_001586604.1 DUF5983 family protein -
PT284_RS23260 (4643181) 4643181..4643357 + 177 WP_001586605.1 DUF957 domain-containing protein -
PT284_RS23265 (4643463) 4643463..4643612 + 150 Protein_4395 hypothetical protein -
PT284_RS23270 (4644268) 4644268..4647159 + 2892 WP_000580534.1 SNF2-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimB / fimE 4636081..4662226 26145


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T272510 WP_000854765.1 NZ_CP117959:4642302-4642676 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT272510 WP_001540478.1 NZ_CP117959:4641844-4642212 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References