Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2929762..2930416 Replicon chromosome
Accession NZ_CP117959
Organism Escherichia coli strain B-2207

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag PT284_RS14960 Protein ID WP_000244777.1
Coordinates 2929762..2930169 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PT284_RS14965 Protein ID WP_000354046.1
Coordinates 2930150..2930416 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT284_RS14940 (2925719) 2925719..2927452 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
PT284_RS14945 (2927458) 2927458..2928168 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PT284_RS14950 (2928193) 2928193..2929089 - 897 WP_042091714.1 site-specific tyrosine recombinase XerD -
PT284_RS14955 (2929201) 2929201..2929722 + 522 WP_001055874.1 flavodoxin FldB -
PT284_RS14960 (2929762) 2929762..2930169 - 408 WP_000244777.1 protein YgfX Toxin
PT284_RS14965 (2930150) 2930150..2930416 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PT284_RS14970 (2930659) 2930659..2931639 + 981 WP_001514522.1 tRNA-modifying protein YgfZ -
PT284_RS14975 (2931835) 2931835..2932494 - 660 WP_000250274.1 hemolysin III family protein -
PT284_RS14980 (2932658) 2932658..2932969 - 312 WP_001514524.1 N(4)-acetylcytidine aminohydrolase -
PT284_RS14985 (2933014) 2933014..2934447 + 1434 WP_001514525.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T272504 WP_000244777.1 NZ_CP117959:c2930169-2929762 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT272504 WP_000354046.1 NZ_CP117959:c2930416-2930150 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References