Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 170478..171096 Replicon chromosome
Accession NZ_CP117959
Organism Escherichia coli strain B-2207

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PT284_RS01555 Protein ID WP_001291435.1
Coordinates 170478..170696 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PT284_RS01560 Protein ID WP_000344800.1
Coordinates 170722..171096 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT284_RS01525 (165651) 165651..166271 + 621 WP_001267012.1 recombinase family protein -
PT284_RS01530 (166489) 166489..166716 + 228 WP_024183738.1 DUF2188 domain-containing protein -
PT284_RS01535 (167060) 167060..167413 + 354 WP_000878140.1 DUF1428 domain-containing protein -
PT284_RS01540 (167455) 167455..169005 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PT284_RS01545 (169169) 169169..169639 - 471 WP_000136192.1 YlaC family protein -
PT284_RS01550 (169755) 169755..170306 - 552 WP_000102564.1 maltose O-acetyltransferase -
PT284_RS01555 (170478) 170478..170696 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PT284_RS01560 (170722) 170722..171096 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PT284_RS01565 (171642) 171642..174791 - 3150 WP_066009150.1 efflux RND transporter permease AcrB -
PT284_RS01570 (174814) 174814..176007 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T272491 WP_001291435.1 NZ_CP117959:c170696-170478 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT272491 WP_000344800.1 NZ_CP117959:c171096-170722 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References