Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 62338..62885 Replicon plasmid unnamed1
Accession NZ_CP117958
Organism Escherichia coli strain B-2207

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PT284_RS00355 Protein ID WP_244448951.1
Coordinates 62338..62616 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag PT284_RS00360 Protein ID WP_000079941.1
Coordinates 62616..62885 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT284_RS00330 (58270) 58270..58983 + 714 WP_032269703.1 MgtC/SapB family protein -
PT284_RS00335 (59140) 59140..59379 - 240 Protein_66 IS4 family transposase -
PT284_RS00340 (59672) 59672..60694 - 1023 WP_032269704.1 IS110 family transposase -
PT284_RS00345 (60854) 60854..61312 - 459 WP_001236004.1 hypothetical protein -
PT284_RS00350 (61453) 61453..62292 - 840 WP_001402900.1 3'-5' exonuclease -
PT284_RS00355 (62338) 62338..62616 - 279 WP_244448951.1 type II toxin-antitoxin system toxin YacB Toxin
PT284_RS00360 (62616) 62616..62885 - 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PT284_RS00365 (63631) 63631..64377 - 747 Protein_72 IS21-like element ISEc12 family helper ATPase IstB -
PT284_RS00370 (64392) 64392..65165 - 774 Protein_73 IS21-like element ISEc12 family transposase -
PT284_RS00375 (65231) 65231..66577 + 1347 WP_274270680.1 IS4-like element IS4 family transposase -
PT284_RS00380 (66592) 66592..67371 - 780 Protein_75 IS21-like element ISEc12 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iucA / iucB / iucB / iucC / iucD / iutA 1..122293 122293
- inside IScluster/Tn - - 59672..67371 7699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10744.34 Da        Isoelectric Point: 8.4615

>T272483 WP_244448951.1 NZ_CP117958:c62616-62338 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASSLAGQPYKGRNGRVEGARELVIHPHFVLVYEVDSQWGKVY
ILRVLHTTQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT272483 WP_000079941.1 NZ_CP117958:c62885-62616 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References