Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-DinJ
Location 1217412..1217964 Replicon chromosome
Accession NZ_CP117956
Organism Bifidobacterium adolescentis strain LMG 10502

Toxin (Protein)


Gene name mazF Uniprot ID A0A1X2ZBV4
Locus tag PT259_RS05325 Protein ID WP_011743342.1
Coordinates 1217412..1217732 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A087DRE9
Locus tag PT259_RS05330 Protein ID WP_033494219.1
Coordinates 1217719..1217964 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT259_RS05295 1212512..1212793 + 282 WP_041777341.1 type II toxin-antitoxin system YafQ family toxin -
PT259_RS05300 1212812..1213009 - 198 WP_041777342.1 hypothetical protein -
PT259_RS05305 1213113..1215251 - 2139 WP_011743338.1 DUF2075 domain-containing protein -
PT259_RS05310 1215311..1215634 + 324 WP_039198631.1 nucleotide pyrophosphohydrolase -
PT259_RS05315 1216086..1216970 + 885 WP_085379702.1 Abi family protein -
PT259_RS05320 1217062..1217415 - 354 WP_011743341.1 nucleotidyltransferase domain-containing protein -
PT259_RS05325 1217412..1217732 - 321 WP_011743342.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PT259_RS05330 1217719..1217964 - 246 WP_033494219.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PT259_RS05335 1218383..1219003 + 621 WP_231836951.1 hypothetical protein -
PT259_RS05340 1219021..1219677 - 657 WP_041777344.1 ECF transporter S component -
PT259_RS05345 1219974..1220747 - 774 WP_011743347.1 GNAT family N-acetyltransferase -
PT259_RS05350 1220906..1221658 + 753 WP_011743348.1 YdcF family protein -
PT259_RS05355 1221690..1222313 - 624 WP_011743349.1 3'-5' exonuclease -
PT259_RS05360 1222370..1222615 - 246 WP_011743350.1 homocysteine S-methyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-52)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11848.88 Da        Isoelectric Point: 7.1665

>T272476 WP_011743342.1 NZ_CP117956:c1217732-1217412 [Bifidobacterium adolescentis]
MRRGEIWTVLADGYARKPRPVVVVQNDEIEGFDSTVVCLMISFTSDDMTTRVKVPPTAQNGLIKISWVMTEKILAVHTSA
LGQRIGILEDDVMRQVEKKLAHVLAL

Download         Length: 321 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9328.31 Da        Isoelectric Point: 4.0948

>AT272476 WP_033494219.1 NZ_CP117956:c1217964-1217719 [Bifidobacterium adolescentis]
MVVQLATRVDDDQAEEFRETTKKLGLSTADALRMFVSSFNEYQGFPYQVRVRQVAEPFENEREASDFANDLSMRMIADEE
G

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X2ZBV4

Antitoxin

Source ID Structure
AlphaFold DB A0A087DRE9

References