Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafQ-relB/YafQ-DinJ
Location 1212259..1212793 Replicon chromosome
Accession NZ_CP117956
Organism Bifidobacterium adolescentis strain LMG 10502

Toxin (Protein)


Gene name yafQ Uniprot ID A0A1X2ZBX5
Locus tag PT259_RS05295 Protein ID WP_041777341.1
Coordinates 1212512..1212793 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V8QB77
Locus tag PT259_RS05290 Protein ID WP_041777340.1
Coordinates 1212259..1212519 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT259_RS05275 1208286..1210061 + 1776 WP_011743335.1 glycoside hydrolase family 13 protein -
PT259_RS05280 1210115..1211482 + 1368 WP_011743336.1 ABC transporter substrate-binding protein -
PT259_RS05285 1211601..1212065 + 465 WP_041777339.1 D-aminoacyl-tRNA deacylase -
PT259_RS05290 1212259..1212519 + 261 WP_041777340.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PT259_RS05295 1212512..1212793 + 282 WP_041777341.1 type II toxin-antitoxin system YafQ family toxin Toxin
PT259_RS05300 1212812..1213009 - 198 WP_041777342.1 hypothetical protein -
PT259_RS05305 1213113..1215251 - 2139 WP_011743338.1 DUF2075 domain-containing protein -
PT259_RS05310 1215311..1215634 + 324 WP_039198631.1 nucleotide pyrophosphohydrolase -
PT259_RS05315 1216086..1216970 + 885 WP_085379702.1 Abi family protein -
PT259_RS05320 1217062..1217415 - 354 WP_011743341.1 nucleotidyltransferase domain-containing protein -
PT259_RS05325 1217412..1217732 - 321 WP_011743342.1 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11090.90 Da        Isoelectric Point: 10.2491

>T272475 WP_041777341.1 NZ_CP117956:1212512-1212793 [Bifidobacterium adolescentis]
MLKSVFRTTQFKKDFKVLLKKHYSPDKLKQAIDALMAQNKQLLSTKYRDHPLTGNWKGYREIHIEGDWLVIYRVEKQELQ
LVLTRTGSHDDLF

Download         Length: 282 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9656.83 Da        Isoelectric Point: 4.6028

>AT272475 WP_041777340.1 NZ_CP117956:1212259-1212519 [Bifidobacterium adolescentis]
MSDTATISFRTDPAIKREAKELYADMGMDLSTAINIFLRQSIRENGMPFKITRDNPSSIEARRQAETHDGESFTSTDALM
KDLLDA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X2ZBX5

Antitoxin

Source ID Structure
AlphaFold DB A0A1V8QB77

References