Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1557379..1557926 Replicon chromosome
Accession NZ_CP117886
Organism Serratia ureilytica strain KML.E1

Toxin (Protein)


Gene name ccdB Uniprot ID A0A380ADA6
Locus tag PTZ17_RS07555 Protein ID WP_025302144.1
Coordinates 1557618..1557926 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag PTZ17_RS07550 Protein ID WP_025302143.1
Coordinates 1557379..1557615 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ17_RS07535 (PTZ17_07535) 1553865..1555400 + 1536 WP_182073871.1 glutathione ABC transporter substrate-binding protein GsiB -
PTZ17_RS07540 (PTZ17_07540) 1555453..1556373 + 921 WP_025302141.1 glutathione ABC transporter permease GsiC -
PTZ17_RS07545 (PTZ17_07545) 1556383..1557291 + 909 WP_015377211.1 glutathione ABC transporter permease GsiD -
PTZ17_RS07550 (PTZ17_07550) 1557379..1557615 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PTZ17_RS07555 (PTZ17_07555) 1557618..1557926 + 309 WP_025302144.1 CcdB family protein Toxin
PTZ17_RS07560 (PTZ17_07560) 1557963..1558805 - 843 WP_015377214.1 S-formylglutathione hydrolase -
PTZ17_RS07565 (PTZ17_07565) 1558820..1559944 - 1125 WP_033642438.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
PTZ17_RS07570 (PTZ17_07570) 1559975..1560895 - 921 WP_016928453.1 LysR family transcriptional regulator -
PTZ17_RS07575 (PTZ17_07575) 1561001..1562158 + 1158 WP_033650593.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11504.32 Da        Isoelectric Point: 5.0196

>T272461 WP_025302144.1 NZ_CP117886:1557618-1557926 [Serratia ureilytica]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT272461 WP_025302143.1 NZ_CP117886:1557379-1557615 [Serratia ureilytica]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380ADA6

Antitoxin

Source ID Structure

References