Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2136681..2137340 Replicon chromosome
Accession NZ_CP117884
Organism Lacticaseibacillus sp. KACC 23028

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PQ472_RS10500 Protein ID WP_274259674.1
Coordinates 2137158..2137340 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PQ472_RS10495 Protein ID WP_274259673.1
Coordinates 2136681..2137139 (-) Length 153 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ472_RS10470 (PQ472_10470) 2132840..2133712 + 873 WP_274259668.1 hypothetical protein -
PQ472_RS10475 (PQ472_10475) 2133911..2134570 + 660 WP_274259669.1 hypothetical protein -
PQ472_RS10480 (PQ472_10480) 2134696..2134827 - 132 WP_274259670.1 hypothetical protein -
PQ472_RS10485 (PQ472_10485) 2135095..2135952 - 858 WP_274259671.1 TPM domain-containing protein -
PQ472_RS10490 (PQ472_10490) 2135961..2136554 - 594 WP_274262280.1 LemA family protein -
PQ472_RS10495 (PQ472_10495) 2136681..2137139 - 459 WP_274259673.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PQ472_RS10500 (PQ472_10500) 2137158..2137340 - 183 WP_274259674.1 type II toxin-antitoxin system HicA family toxin Toxin
PQ472_RS10505 (PQ472_10505) 2137473..2137955 - 483 WP_274259676.1 AAA family ATPase -
PQ472_RS10510 (PQ472_10510) 2138105..2139046 - 942 WP_274259678.1 dihydroorotate oxidase -
PQ472_RS10515 (PQ472_10515) 2139030..2140286 - 1257 WP_274259680.1 MFS transporter -
PQ472_RS10520 (PQ472_10520) 2140567..2141298 + 732 WP_274259682.1 orotidine-5'-phosphate decarboxylase -
PQ472_RS10525 (PQ472_10525) 2141291..2141932 + 642 WP_274259684.1 orotate phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6666.90 Da        Isoelectric Point: 12.0707

>T272457 WP_274259674.1 NZ_CP117884:c2137340-2137158 [Lacticaseibacillus sp. KACC 23028]
VPMTQRQMVRLLMKNGWFKTGGGKGSHIKMAKAGKRPITVPHGELRQPTENAIRKQAGIE

Download         Length: 183 bp

Antitoxin


Download         Length: 153 a.a.        Molecular weight: 17051.11 Da        Isoelectric Point: 4.5141

>AT272457 WP_274259673.1 NZ_CP117884:c2137139-2136681 [Lacticaseibacillus sp. KACC 23028]
MFVTYPAYFYYSKQDAVHFFVTFPDFNLSATQGTDVADAMYMASDWLGINVADLVEHERALPTPSAMGELSLTDNPFFND
DADLRSSFDATQSFVSMVGVNIDSYLNQSQPIKKTLTIPKWANDRGKKLHINFSETLTEAIANLPNPHSLQK

Download         Length: 459 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References