272453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 707433..708958 Replicon chromosome
Accession NZ_CP117881
Organism Novosphingobium sp. KACC 22771

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag PQ467_RS03170 Protein ID WP_274175105.1
Coordinates 707645..708958 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag PQ467_RS03165 Protein ID WP_274176076.1
Coordinates 707433..707645 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ467_RS03155 (PQ467_03155) 703589..704278 + 690 WP_274175103.1 ribbon-helix-helix domain-containing protein -
PQ467_RS03160 (PQ467_03160) 704275..707298 + 3024 WP_274175104.1 MobF family relaxase -
PQ467_RS03165 (PQ467_03165) 707433..707645 + 213 WP_274176076.1 helix-turn-helix domain-containing protein Antitoxin
PQ467_RS03170 (PQ467_03170) 707645..708958 + 1314 WP_274175105.1 type II toxin-antitoxin system HipA family toxin Toxin
PQ467_RS03175 (PQ467_03175) 708962..709876 - 915 WP_274175106.1 HNH endonuclease -
PQ467_RS03180 (PQ467_03180) 709944..710657 + 714 WP_274175107.1 hypothetical protein -
PQ467_RS03185 (PQ467_03185) 710659..712626 - 1968 WP_274175108.1 hypothetical protein -
PQ467_RS03190 (PQ467_03190) 712927..713370 - 444 WP_274175109.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 681206..712955 31749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-63)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 46762.16 Da        Isoelectric Point: 5.6347

>T272453 WP_274175105.1 NZ_CP117881:707645-708958 [Novosphingobium sp. KACC 22771]
MVDVPIHYEGRRVATISADGQATRLAYDDSWLASEDRFPVSLAMPIRPEPYDESLVLPWLMNLLPEGEPLRAMTRALGAA
PEDALGLIAQTGSDLAGALSMAPQPTRGEPAYRAIPDADALERILNELPARPFLVGEDGVSMSLAGAQEKLPVAVIDGQI
AVPTNGAPSTHILKPDNPRLSGSVQNEALCMVLARRIGLNVAPVTTGVAGGRSYLLVERYDRAGIGGAVRRMHQEDFCQA
LGRAPAAKYEFNGTGTRGPSIADMFALVRQHMTARDITRLLDAVIFNIAIGNVDSHAKNYSILLGAGAPELAPLYDLMTG
LAWVNITQNHAQAIGGQRRGRHIYGRHWRRMAEAAGLAARGTIQRVEHVTARLLRELPAAVEEVAAMPAGAAMLDIFAKE
IGERASEVRAHAGQEGVPDVTDTASDDQTNDATAYRG

Download         Length: 1314 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7119.22 Da        Isoelectric Point: 10.7685

>AT272453 WP_274176076.1 NZ_CP117881:707433-707645 [Novosphingobium sp. KACC 22771]
MIDNATQFGAAIASARKALGLTQRELALAINSGERFIVDLEAGKPTAQLGKALAAAKAVGLRLTANGPQS

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References