Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 4063575..4064210 Replicon chromosome
Accession NZ_CP117876
Organism Paenibacillus sp. KACC 21273

Toxin (Protein)


Gene name pemK Uniprot ID A0A1E3L8D9
Locus tag PQ460_RS17920 Protein ID WP_069326106.1
Coordinates 4063575..4063925 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag PQ460_RS17925 Protein ID WP_069326107.1
Coordinates 4063929..4064210 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ460_RS17905 (PQ460_17905) 4059928..4060413 - 486 WP_274170638.1 SprT family protein -
PQ460_RS17910 (PQ460_17910) 4060545..4060910 + 366 WP_274170639.1 hydrolase/acyltransferase -
PQ460_RS17915 (PQ460_17915) 4061156..4063381 - 2226 WP_274170640.1 Tex family protein -
PQ460_RS17920 (PQ460_17920) 4063575..4063925 - 351 WP_069326106.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PQ460_RS17925 (PQ460_17925) 4063929..4064210 - 282 WP_069326107.1 ribbon-helix-helix protein, CopG family Antitoxin
PQ460_RS17930 (PQ460_17930) 4064433..4065626 - 1194 WP_273616255.1 alanine racemase -
PQ460_RS17935 (PQ460_17935) 4065869..4066534 - 666 WP_274170641.1 hypothetical protein -
PQ460_RS17940 (PQ460_17940) 4066602..4067357 - 756 WP_273615299.1 hypothetical protein -
PQ460_RS17945 (PQ460_17945) 4067359..4068615 - 1257 WP_274170642.1 SPFH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-40)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12927.91 Da        Isoelectric Point: 6.4842

>T272451 WP_069326106.1 NZ_CP117876:c4063925-4063575 [Paenibacillus sp. KACC 21273]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKSHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRRVHDALQISLGLVEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10773.41 Da        Isoelectric Point: 4.9059

>AT272451 WP_069326107.1 NZ_CP117876:c4064210-4063929 [Paenibacillus sp. KACC 21273]
MDNMQNAQSIMIRLPDQLLQEVDGIAALEDSDRSELIRKATKIYLTERKKRYIREAMQRGYMEMAKINLRIACEAFHAEE
EADITLDRLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3L8D9

Antitoxin

Source ID Structure

References