Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2139685..2140163 Replicon chromosome
Accession NC_017628
Organism Escherichia coli IHE3034

Toxin (Protein)


Gene name parE_1 Uniprot ID D8A5B3
Locus tag ECOK1_RS11120 Protein ID WP_000936799.1
Coordinates 2139876..2140163 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D8A5B4
Locus tag ECOK1_RS11115 Protein ID WP_000100899.1
Coordinates 2139685..2139876 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOK1_RS27865 2135178..2135456 - 279 WP_024193993.1 hypothetical protein -
ECOK1_RS11080 2135624..2135779 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
ECOK1_RS11085 2136017..2136682 - 666 WP_000150294.1 epoxyqueuosine reductase QueH -
ECOK1_RS11090 2136857..2137282 - 426 WP_001151152.1 DUF977 family protein -
ECOK1_RS11095 2137323..2138393 - 1071 WP_001262355.1 hypothetical protein -
ECOK1_RS11100 2138465..2138890 - 426 WP_000693918.1 Rha family transcriptional regulator -
ECOK1_RS11105 2138874..2139146 - 273 WP_000887447.1 helix-turn-helix domain-containing protein -
ECOK1_RS11110 2139256..2139657 + 402 WP_001329851.1 helix-turn-helix domain-containing protein -
ECOK1_RS11115 2139685..2139876 + 192 WP_000100899.1 hypothetical protein Antitoxin
ECOK1_RS11120 2139876..2140163 + 288 WP_000936799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECOK1_RS11125 2140435..2140587 + 153 WP_000379609.1 DUF1391 family protein -
ECOK1_RS11130 2140599..2140973 + 375 WP_001553098.1 hypothetical protein -
ECOK1_RS11135 2140963..2141184 - 222 WP_000202161.1 hypothetical protein -
ECOK1_RS11145 2141752..2142600 + 849 WP_000935606.1 Rha family phage regulatory protein -
ECOK1_RS11150 2142646..2142867 + 222 WP_000560231.1 cell division protein FtsZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ybtS / ybtX / ybtQ / ybtP 2106750..2155801 49051


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10929.85 Da        Isoelectric Point: 10.1360

>T27245 WP_000936799.1 NC_017628:2139876-2140163 [Escherichia coli IHE3034]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVATSSIE
IANIVHARRQFPFPI

Download         Length: 288 bp

>T27245 NC_017628:2139876-2140163 [Escherichia coli IHE3034]
ATGTTACCCATTTTGTGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCGTAGCCTATATTGCTAAGGAAAATATTCC
TGCAGCACGCAGACTAAAAATACGGATTGAAACGTCTGTTTTAGCCCTCTCTGAGCATCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTGTACCGAGTAGCAACTTCAAGCATTGAA
ATTGCAAATATTGTGCATGCCCGCCGACAATTTCCCTTCCCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7035.80 Da        Isoelectric Point: 4.0270

>AT27245 WP_000100899.1 NC_017628:2139685-2139876 [Escherichia coli IHE3034]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT27245 NC_017628:2139685-2139876 [Escherichia coli IHE3034]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTACGCGC
TAAAGTGGCGTCAAGCCTTGCAGACCCTCGTCCCTCAATTCCACATGATGAGGTAATGGCTGAAATGGAGAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8A5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A161RC07

References