Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1740035..1740588 Replicon chromosome
Accession NZ_CP117874
Organism Pectobacterium carotovorum subsp. carotovorum strain ZJ-4-2

Toxin (Protein)


Gene name ccdB Uniprot ID A0A1V2R684
Locus tag PSR30_RS07710 Protein ID WP_039360030.1
Coordinates 1740274..1740588 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A837DPD8
Locus tag PSR30_RS07705 Protein ID WP_039473880.1
Coordinates 1740035..1740271 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR30_RS07695 (PSR30_07695) 1736843..1738714 - 1872 WP_039473476.1 AAA family ATPase -
PSR30_RS07700 (PSR30_07700) 1739484..1739874 + 391 Protein_1498 ArdC family protein -
PSR30_RS07705 (PSR30_07705) 1740035..1740271 + 237 WP_039473880.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PSR30_RS07710 (PSR30_07710) 1740274..1740588 + 315 WP_039360030.1 CcdB family protein Toxin
PSR30_RS07720 (PSR30_07720) 1741250..1742047 - 798 WP_010307981.1 DgsA anti-repressor MtfA -
PSR30_RS07730 (PSR30_07730) 1742289..1742675 - 387 WP_274215176.1 lysozyme inhibitor LprI family protein -
PSR30_RS07735 (PSR30_07735) 1742746..1742887 - 142 Protein_1503 IS5/IS1182 family transposase -
PSR30_RS07740 (PSR30_07740) 1743062..1744483 - 1422 WP_274215177.1 hypothetical protein -
PSR30_RS07745 (PSR30_07745) 1744620..1744853 + 234 WP_274215178.1 hypothetical protein -
PSR30_RS07750 (PSR30_07750) 1744908..1745330 + 423 WP_274215179.1 DUF2946 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1716286..1744853 28567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11535.48 Da        Isoelectric Point: 7.9859

>T272446 WP_039360030.1 NZ_CP117874:1740274-1740588 [Pectobacterium carotovorum subsp. carotovorum]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGF

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8983.05 Da        Isoelectric Point: 7.1672

>AT272446 WP_039473880.1 NZ_CP117874:1740035-1740271 [Pectobacterium carotovorum subsp. carotovorum]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRHEAKKWQEENREALAALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V2R684

Antitoxin

Source ID Structure
AlphaFold DB A0A837DPD8

References