Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 196434..197051 Replicon chromosome
Accession NZ_CP117874
Organism Pectobacterium carotovorum subsp. carotovorum strain ZJ-4-2

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag PSR30_RS00840 Protein ID WP_010281507.1
Coordinates 196872..197051 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PSR30_RS00835 Protein ID WP_274214674.1
Coordinates 196434..196844 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR30_RS00820 (PSR30_00820) 192298..193341 - 1044 WP_039363341.1 DNA-binding transcriptional regulator CytR -
PSR30_RS00825 (PSR30_00825) 193651..195849 - 2199 WP_039535645.1 primosomal protein N' -
PSR30_RS00830 (PSR30_00830) 196122..196337 + 216 WP_010281510.1 50S ribosomal protein L31 -
PSR30_RS00835 (PSR30_00835) 196434..196844 - 411 WP_274214674.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PSR30_RS00840 (PSR30_00840) 196872..197051 - 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
PSR30_RS00845 (PSR30_00845) 197150..198160 - 1011 WP_180781350.1 iron ABC transporter permease -
PSR30_RS00850 (PSR30_00850) 198157..199119 - 963 WP_180781351.1 ABC transporter substrate-binding protein -
PSR30_RS00855 (PSR30_00855) 199129..199926 - 798 WP_039535641.1 ABC transporter ATP-binding protein -
PSR30_RS00860 (PSR30_00860) 200145..200462 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
PSR30_RS00865 (PSR30_00865) 200650..201810 + 1161 WP_010299271.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T272437 WP_010281507.1 NZ_CP117874:c197051-196872 [Pectobacterium carotovorum subsp. carotovorum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14546.50 Da        Isoelectric Point: 4.5502

>AT272437 WP_274214674.1 NZ_CP117874:c196844-196434 [Pectobacterium carotovorum subsp. carotovorum]
MFYPIAIEAGDKTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure

References