Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 100870..101455 Replicon plasmid pKOB2
Accession NZ_CP117858
Organism Komagataeibacter oboediens strain NCIB 8034

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LV478_RS00545 Protein ID WP_275877766.1
Coordinates 101126..101455 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5YEQ9
Locus tag LV478_RS00540 Protein ID WP_010511780.1
Coordinates 100870..101133 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV478_RS00510 (LV478_00510) 96119..96550 - 432 Protein_101 transposase -
LV478_RS00520 (LV478_00520) 97899..98234 - 336 Protein_103 helix-turn-helix domain-containing protein -
LV478_RS00525 (LV478_00525) 98340..99578 - 1239 WP_025440189.1 type II toxin-antitoxin system HipA family toxin -
LV478_RS00530 (LV478_00530) 99575..99877 - 303 WP_025440188.1 helix-turn-helix transcriptional regulator -
LV478_RS00535 (LV478_00535) 100167..100580 + 414 Protein_106 transposase -
LV478_RS00540 (LV478_00540) 100870..101133 + 264 WP_010511780.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LV478_RS00545 (LV478_00545) 101126..101455 + 330 WP_275877766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LV478_RS00550 (LV478_00550) 102587..103528 + 942 WP_275877767.1 epoxide hydrolase -
LV478_RS00555 (LV478_00560) 103778..104389 - 612 WP_275877768.1 LysR substrate-binding domain-containing protein -
LV478_RS00560 (LV478_00565) 104411..105274 + 864 Protein_111 MFS transporter -
LV478_RS00565 (LV478_00570) 105342..105776 + 435 WP_275877769.1 GFA family protein -
LV478_RS00570 (LV478_00575) 105787..105882 - 96 Protein_113 transmembrane phosphoesterase -
LV478_RS00575 (LV478_00580) 105905..106024 + 120 Protein_114 FAD-dependent monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..173561 173561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12478.11 Da        Isoelectric Point: 5.2494

>T272423 WP_275877766.1 NZ_CP117858:101126-101455 [Komagataeibacter oboediens]
MTEYAIEFDDRALREWDGLDGSIRRKFEKKLEKLVLTPHSPGNELHGDLAGFYKIKLRQDDYQVVEQRIVIFVIAMGRRE
DDEIYTAATGRVPETPVTAANPGRLGTDR

Download         Length: 330 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9629.04 Da        Isoelectric Point: 7.3200

>AT272423 WP_010511780.1 NZ_CP117858:100870-101133 [Komagataeibacter oboediens]
MSAVTFRVDDALKSAAVAKLSAHGLSLSDVLRDTLAYIAETGQPPVKRRLVTDEDARLIEIVRERLADPAPRHRMTLAEL
KARHPDD

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4J448

References