Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1292512..1293429 Replicon chromosome
Accession NZ_CP117857
Organism Bacillus velezensis strain PT4

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A807M4S7
Locus tag PO845_RS06675 Protein ID WP_060674890.1
Coordinates 1292683..1293429 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag PO845_RS06670 Protein ID WP_003154807.1
Coordinates 1292512..1292682 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO845_RS06630 (PO845_06630) 1287724..1289313 + 1590 WP_053573489.1 hypothetical protein -
PO845_RS06635 (PO845_06635) 1289326..1289751 + 426 WP_053573490.1 hypothetical protein -
PO845_RS06640 (PO845_06640) 1289756..1289953 + 198 WP_012117366.1 XkdX family protein -
PO845_RS06645 (PO845_06645) 1290010..1290771 + 762 WP_060674886.1 hypothetical protein -
PO845_RS06650 (PO845_06650) 1290823..1291086 + 264 WP_031378810.1 hemolysin XhlA family protein -
PO845_RS06655 (PO845_06655) 1291100..1291363 + 264 WP_003154813.1 phage holin -
PO845_RS06660 (PO845_06660) 1291377..1292255 + 879 WP_060674888.1 N-acetylmuramoyl-L-alanine amidase -
PO845_RS06665 (PO845_06665) 1292290..1292415 - 126 WP_003154809.1 hypothetical protein -
PO845_RS06670 (PO845_06670) 1292512..1292682 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
PO845_RS06675 (PO845_06675) 1292683..1293429 - 747 WP_060674890.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PO845_RS06680 (PO845_06680) 1293535..1294533 - 999 WP_003154805.1 inorganic phosphate transporter -
PO845_RS06685 (PO845_06685) 1294546..1295163 - 618 WP_003154804.1 DUF47 domain-containing protein -
PO845_RS06690 (PO845_06690) 1295449..1296765 - 1317 WP_007610842.1 amino acid permease -
PO845_RS06695 (PO845_06695) 1297088..1298038 + 951 WP_031378808.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29081.56 Da        Isoelectric Point: 4.7755

>T272422 WP_060674890.1 NZ_CP117857:c1293429-1292683 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGITRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMSDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT272422 WP_003154807.1 NZ_CP117857:c1292682-1292512 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807M4S7

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References