Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 4736266..4737085 Replicon chromosome
Accession NZ_CP117853
Organism Klebsiella michiganensis strain 2020CK-00215

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag PUO96_RS22285 Protein ID WP_004110819.1
Coordinates 4736828..4737085 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag PUO96_RS22280 Protein ID WP_064405206.1
Coordinates 4736266..4736817 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO96_RS22260 (PUO96_22260) 4732488..4733396 - 909 WP_064405202.1 transcriptional regulator GcvA -
PUO96_RS22265 (PUO96_22265) 4733516..4734403 + 888 WP_064405204.1 DMT family transporter -
PUO96_RS22270 (PUO96_22270) 4734620..4735366 - 747 WP_224244006.1 class I SAM-dependent methyltransferase -
PUO96_RS22275 (PUO96_22275) 4735790..4736152 - 363 Protein_4381 class I SAM-dependent methyltransferase -
PUO96_RS22280 (PUO96_22280) 4736266..4736817 - 552 WP_064405206.1 N-acetyltransferase Antitoxin
PUO96_RS22285 (PUO96_22285) 4736828..4737085 - 258 WP_004110819.1 YjhX family toxin Toxin
PUO96_RS22290 (PUO96_22290) 4737761..4738945 + 1185 WP_014228054.1 mannonate dehydratase -
PUO96_RS22295 (PUO96_22295) 4739019..4740503 + 1485 WP_064405208.1 fructuronate reductase -
PUO96_RS22300 (PUO96_22300) 4740642..4741418 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T272420 WP_004110819.1 NZ_CP117853:c4737085-4736828 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19976.78 Da        Isoelectric Point: 6.4897

>AT272420 WP_064405206.1 NZ_CP117853:c4736817-4736266 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References