Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 917855..918512 Replicon chromosome
Accession NZ_CP117853
Organism Klebsiella michiganensis strain 2020CK-00215

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag PUO96_RS04410 Protein ID WP_064404221.1
Coordinates 918102..918512 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag PUO96_RS04405 Protein ID WP_004124953.1
Coordinates 917855..918121 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO96_RS04390 (PUO96_04390) 913089..913514 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
PUO96_RS04395 (PUO96_04395) 913635..916433 - 2799 WP_014226794.1 transcriptional regulator DagR -
PUO96_RS04400 (PUO96_04400) 916627..917610 - 984 WP_014226793.1 tRNA-modifying protein YgfZ -
PUO96_RS04405 (PUO96_04405) 917855..918121 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
PUO96_RS04410 (PUO96_04410) 918102..918512 + 411 WP_064404221.1 protein YgfX Toxin
PUO96_RS04415 (PUO96_04415) 918521..919042 - 522 WP_014226792.1 flavodoxin FldB -
PUO96_RS04420 (PUO96_04420) 919164..920060 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
PUO96_RS04425 (PUO96_04425) 920083..920796 + 714 WP_274229438.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PUO96_RS04430 (PUO96_04430) 920802..922535 + 1734 WP_032751182.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16122.97 Da        Isoelectric Point: 10.9455

>T272413 WP_064404221.1 NZ_CP117853:918102-918512 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDSGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT272413 WP_004124953.1 NZ_CP117853:917855-918121 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References