272404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4324982..4325602 Replicon chromosome
Accession NZ_CP117852
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28R

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PTZ66_RS21175 Protein ID WP_001280991.1
Coordinates 4325384..4325602 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PTZ66_RS21170 Protein ID WP_000344807.1
Coordinates 4324982..4325356 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ66_RS21160 (4320121) 4320121..4321314 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PTZ66_RS21165 (4321337) 4321337..4324486 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PTZ66_RS21170 (4324982) 4324982..4325356 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PTZ66_RS21175 (4325384) 4325384..4325602 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PTZ66_RS21180 (4325781) 4325781..4326332 + 552 WP_001278793.1 maltose O-acetyltransferase -
PTZ66_RS21185 (4326448) 4326448..4326918 + 471 WP_000136183.1 YlaC family protein -
PTZ66_RS21190 (4326974) 4326974..4327114 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PTZ66_RS21195 (4327120) 4327120..4327380 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PTZ66_RS21200 (4327605) 4327605..4329155 + 1551 WP_000213140.1 EAL domain-containing protein -
PTZ66_RS21210 (4329386) 4329386..4329775 + 390 WP_000961285.1 MGMT family protein -
PTZ66_RS21215 (4329808) 4329808..4330377 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T272404 WP_001280991.1 NZ_CP117852:4325384-4325602 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT272404 WP_000344807.1 NZ_CP117852:4324982-4325356 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References