272403

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 3283225..3283747 Replicon chromosome
Accession NZ_CP117852
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28R

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag PTZ66_RS15945 Protein ID WP_000221345.1
Coordinates 3283463..3283747 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PTZ66_RS15940 Protein ID WP_000885424.1
Coordinates 3283225..3283473 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ66_RS15910 (3278768) 3278768..3279548 + 781 Protein_3095 helix-turn-helix domain-containing protein -
PTZ66_RS15915 (3279550) 3279550..3280458 - 909 WP_077906523.1 hypothetical protein -
PTZ66_RS15920 (3280731) 3280731..3281063 - 333 WP_017441352.1 DUF1493 family protein -
PTZ66_RS15925 (3281586) 3281586..3281702 - 117 Protein_3098 IS110 family transposase -
PTZ66_RS15930 (3282067) 3282067..3282456 + 390 WP_017441353.1 hypothetical protein -
PTZ66_RS15935 (3282459) 3282459..3282812 + 354 WP_000418733.1 hypothetical protein -
PTZ66_RS15940 (3283225) 3283225..3283473 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PTZ66_RS15945 (3283463) 3283463..3283747 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTZ66_RS15950 (3283918) 3283918..3284307 + 390 WP_001652798.1 RidA family protein -
PTZ66_RS15955 (3284365) 3284365..3285438 - 1074 WP_017441355.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PTZ66_RS15960 (3285631) 3285631..3286119 - 489 WP_017441356.1 MarR family winged helix-turn-helix transcriptional regulator -
PTZ66_RS15965 (3286164) 3286164..3287672 + 1509 WP_017441357.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3274019..3290529 16510
- inside Genomic island - - 3280731..3290529 9798


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T272403 WP_000221345.1 NZ_CP117852:3283463-3283747 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT272403 WP_000885424.1 NZ_CP117852:3283225-3283473 [Salmonella enterica subsp. enterica serovar Mbandaka]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References