272397

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1925147..1925961 Replicon chromosome
Accession NZ_CP117852
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28R

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3W0Q3Z8
Locus tag PTZ66_RS09330 Protein ID WP_017441137.1
Coordinates 1925147..1925674 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A418Z520
Locus tag PTZ66_RS09335 Protein ID WP_017441138.1
Coordinates 1925671..1925961 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ66_RS09300 (1921520) 1921520..1921918 + 399 Protein_1803 cytoplasmic protein -
PTZ66_RS09305 (1922109) 1922109..1922348 + 240 Protein_1804 hypothetical protein -
PTZ66_RS09310 (1922505) 1922505..1923173 + 669 WP_000445914.1 hypothetical protein -
PTZ66_RS09315 (1923200) 1923200..1923694 + 495 WP_000424947.1 hypothetical protein -
PTZ66_RS09320 (1923865) 1923865..1924521 - 657 WP_017441135.1 protein-serine/threonine phosphatase -
PTZ66_RS09325 (1924859) 1924859..1925074 + 216 Protein_1808 IS5/IS1182 family transposase -
PTZ66_RS09330 (1925147) 1925147..1925674 - 528 WP_017441137.1 GNAT family N-acetyltransferase Toxin
PTZ66_RS09335 (1925671) 1925671..1925961 - 291 WP_017441138.1 DUF1778 domain-containing protein Antitoxin
PTZ66_RS09340 (1926231) 1926231..1926431 - 201 Protein_1811 IS3 family transposase -
PTZ66_RS09345 (1926672) 1926672..1926998 + 327 WP_000393295.1 hypothetical protein -
PTZ66_RS09350 (1927271) 1927271..1927618 - 348 WP_001555786.1 DUF1493 family protein -
PTZ66_RS09355 (1927603) 1927603..1928052 - 450 WP_017441139.1 hypothetical protein -
PTZ66_RS09360 (1928484) 1928484..1928927 - 444 WP_017441140.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PTZ66_RS09365 (1929383) 1929383..1930033 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1924934..1935346 10412
- flank IS/Tn - - 1924934..1925074 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19035.89 Da        Isoelectric Point: 9.6420

>T272397 WP_017441137.1 NZ_CP117852:c1925674-1925147 [Salmonella enterica subsp. enterica serovar Mbandaka]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SLKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10721.55 Da        Isoelectric Point: 8.5957

>AT272397 WP_017441138.1 NZ_CP117852:c1925961-1925671 [Salmonella enterica subsp. enterica serovar Mbandaka]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFARPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W0Q3Z8

Antitoxin

Source ID Structure
AlphaFold DB A0A418Z520

References