Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1767191..1767851 Replicon chromosome
Accession NZ_CP117852
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28R

Toxin (Protein)


Gene name cptA Uniprot ID A0A3V4SJP5
Locus tag PTZ66_RS08610 Protein ID WP_000244755.1
Coordinates 1767438..1767851 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PTZ66_RS08605 Protein ID WP_000351186.1
Coordinates 1767191..1767457 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ66_RS08585 (1763120) 1763120..1764553 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
PTZ66_RS08590 (1764711) 1764711..1765022 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PTZ66_RS08595 (1765186) 1765186..1765845 + 660 WP_000250289.1 hemolysin III family protein -
PTZ66_RS08600 (1765961) 1765961..1766941 - 981 WP_017441090.1 tRNA-modifying protein YgfZ -
PTZ66_RS08605 (1767191) 1767191..1767457 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PTZ66_RS08610 (1767438) 1767438..1767851 + 414 WP_000244755.1 protein YgfX Toxin
PTZ66_RS08615 (1767904) 1767904..1768425 - 522 WP_017441091.1 flavodoxin FldB -
PTZ66_RS08620 (1768538) 1768538..1769434 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PTZ66_RS08625 (1769458) 1769458..1770171 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PTZ66_RS08630 (1770177) 1770177..1771910 + 1734 WP_000813392.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16164.10 Da        Isoelectric Point: 10.2118

>T272396 WP_000244755.1 NZ_CP117852:1767438-1767851 [Salmonella enterica subsp. enterica serovar Mbandaka]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT272396 WP_000351186.1 NZ_CP117852:1767191-1767457 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SJP5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References