Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 1201387..1203010 | Replicon | chromosome |
| Accession | NZ_CP117852 | ||
| Organism | Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28R | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | PTZ66_RS05735 | Protein ID | WP_000088046.1 |
| Coordinates | 1201387..1202712 (-) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | PTZ66_RS05740 | Protein ID | WP_024136327.1 |
| Coordinates | 1202717..1203010 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PTZ66_RS05695 (1196408) | 1196408..1196764 | + | 357 | WP_065311124.1 | H-NS family nucleoid-associated regulatory protein | - |
| PTZ66_RS05700 (1197106) | 1197106..1197309 | - | 204 | WP_001194555.1 | hypothetical protein | - |
| PTZ66_RS05705 (1197371) | 1197371..1198228 | - | 858 | WP_000784387.1 | HNH endonuclease signature motif containing protein | - |
| PTZ66_RS05710 (1198244) | 1198244..1198552 | - | 309 | WP_001224687.1 | hypothetical protein | - |
| PTZ66_RS05715 (1199101) | 1199101..1199526 | - | 426 | WP_001043843.1 | hypothetical protein | - |
| PTZ66_RS05720 (1199780) | 1199780..1200595 | - | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
| PTZ66_RS05725 (1200608) | 1200608..1201018 | - | 411 | WP_000985911.1 | hypothetical protein | - |
| PTZ66_RS05730 (1201120) | 1201120..1201326 | - | 207 | WP_000134171.1 | hypothetical protein | - |
| PTZ66_RS05735 (1201387) | 1201387..1202712 | - | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| PTZ66_RS05740 (1202717) | 1202717..1203010 | - | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PTZ66_RS05745 (1203450) | 1203450..1204154 | + | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| PTZ66_RS05750 (1204206) | 1204206..1204328 | - | 123 | Protein_1108 | IS4 family transposase | - |
| PTZ66_RS05755 (1204471) | 1204471..1205331 | + | 861 | WP_000557454.1 | aminoglycoside N-acetyltransferase AAC(3)-IId | - |
| PTZ66_RS05760 (1205344) | 1205344..1205886 | + | 543 | WP_000587837.1 | AAA family ATPase | - |
| PTZ66_RS05765 (1206292) | 1206292..1206555 | - | 264 | WP_237442625.1 | hypothetical protein | - |
| PTZ66_RS05770 (1206579) | 1206579..1206806 | + | 228 | WP_000248278.1 | hypothetical protein | - |
| PTZ66_RS05775 (1206857) | 1206857..1207984 | + | 1128 | WP_014837927.1 | DUF3883 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T272392 WP_000088046.1 NZ_CP117852:c1202712-1201387 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT272392 WP_024136327.1 NZ_CP117852:c1203010-1202717 [Salmonella enterica subsp. enterica serovar Mbandaka]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |