272381

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 3761320..3761842 Replicon chromosome
Accession NZ_CP117851
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_B30R

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag PTZ67_RS18405 Protein ID WP_000221345.1
Coordinates 3761320..3761604 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PTZ67_RS18410 Protein ID WP_000885424.1
Coordinates 3761594..3761842 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ67_RS18385 (3757395) 3757395..3758903 - 1509 WP_017441357.1 FAD-dependent oxidoreductase -
PTZ67_RS18390 (3758948) 3758948..3759436 + 489 WP_017441356.1 MarR family winged helix-turn-helix transcriptional regulator -
PTZ67_RS18395 (3759629) 3759629..3760702 + 1074 WP_017441355.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PTZ67_RS18400 (3760760) 3760760..3761149 - 390 WP_001652798.1 RidA family protein -
PTZ67_RS18405 (3761320) 3761320..3761604 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTZ67_RS18410 (3761594) 3761594..3761842 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PTZ67_RS18415 (3762255) 3762255..3762608 - 354 WP_000418733.1 hypothetical protein -
PTZ67_RS18420 (3762611) 3762611..3763000 - 390 WP_017441353.1 hypothetical protein -
PTZ67_RS18425 (3763365) 3763365..3763481 + 117 Protein_3586 IS110 family transposase -
PTZ67_RS18430 (3764004) 3764004..3764336 + 333 WP_017441352.1 DUF1493 family protein -
PTZ67_RS18435 (3764609) 3764609..3765517 + 909 WP_077906523.1 hypothetical protein -
PTZ67_RS18440 (3765519) 3765519..3766299 - 781 Protein_3589 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3759629..3771048 11419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T272381 WP_000221345.1 NZ_CP117851:c3761604-3761320 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT272381 WP_000885424.1 NZ_CP117851:c3761842-3761594 [Salmonella enterica subsp. enterica serovar Mbandaka]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References