272380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2719466..2720086 Replicon chromosome
Accession NZ_CP117851
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_B30R

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PTZ67_RS13175 Protein ID WP_001280991.1
Coordinates 2719466..2719684 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PTZ67_RS13180 Protein ID WP_000344807.1
Coordinates 2719712..2720086 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ67_RS13135 (2714691) 2714691..2715260 + 570 WP_000779801.1 YbaY family lipoprotein -
PTZ67_RS13140 (2715293) 2715293..2715682 - 390 WP_000961285.1 MGMT family protein -
PTZ67_RS13150 (2715913) 2715913..2717463 - 1551 WP_000213140.1 EAL domain-containing protein -
PTZ67_RS13155 (2717688) 2717688..2717948 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PTZ67_RS13160 (2717954) 2717954..2718094 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PTZ67_RS13165 (2718150) 2718150..2718620 - 471 WP_000136183.1 YlaC family protein -
PTZ67_RS13170 (2718736) 2718736..2719287 - 552 WP_001278793.1 maltose O-acetyltransferase -
PTZ67_RS13175 (2719466) 2719466..2719684 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PTZ67_RS13180 (2719712) 2719712..2720086 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PTZ67_RS13185 (2720582) 2720582..2723731 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PTZ67_RS13190 (2723754) 2723754..2724947 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T272380 WP_001280991.1 NZ_CP117851:c2719684-2719466 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T272380 NZ_CP117851:c2719684-2719466 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT272380 WP_000344807.1 NZ_CP117851:c2720086-2719712 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT272380 NZ_CP117851:c2720086-2719712 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References