Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1346983..1347764 Replicon chromosome
Accession NZ_CP117851
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_B30R

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag PTZ67_RS06720 Protein ID WP_000625911.1
Coordinates 1346983..1347474 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag PTZ67_RS06725 Protein ID WP_001271379.1
Coordinates 1347471..1347764 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ67_RS06695 (1342117) 1342117..1344555 - 2439 WP_017441226.1 F4 (K88) fimbrial usher FaeD -
PTZ67_RS06700 (1344565) 1344565..1345104 - 540 WP_000721295.1 type 1 fimbrial protein -
PTZ67_RS06705 (1345139) 1345139..1345429 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
PTZ67_RS06710 (1346017) 1346017..1346274 + 258 WP_001112996.1 hypothetical protein -
PTZ67_RS06715 (1346520) 1346520..1346768 - 249 Protein_1309 IS481 family transposase -
PTZ67_RS06720 (1346983) 1346983..1347474 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
PTZ67_RS06725 (1347471) 1347471..1347764 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
PTZ67_RS06730 (1348082) 1348082..1348303 + 222 WP_001595143.1 hypothetical protein -
PTZ67_RS06735 (1348569) 1348569..1349444 + 876 WP_017441228.1 AraC family transcriptional regulator -
PTZ67_RS06740 (1349441) 1349441..1349728 + 288 WP_072103482.1 transcriptional regulator RtsB -
PTZ67_RS06745 (1349735) 1349735..1349902 - 168 WP_071527476.1 ATP-binding cassette domain-containing protein -
PTZ67_RS06750 (1349922) 1349922..1350021 + 100 Protein_1316 hypothetical protein -
PTZ67_RS06755 (1350069) 1350069..1350263 + 195 WP_223195369.1 hypothetical protein -
PTZ67_RS06760 (1350557) 1350557..1351462 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 1335373..1349728 14355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T272371 WP_000625911.1 NZ_CP117851:c1347474-1346983 [Salmonella enterica subsp. enterica serovar Mbandaka]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT272371 WP_001271379.1 NZ_CP117851:c1347764-1347471 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References