Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1202304..1202947 Replicon chromosome
Accession NZ_CP117851
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_B30R

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag PTZ67_RS05980 Protein ID WP_017441191.1
Coordinates 1202531..1202947 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag PTZ67_RS05975 Protein ID WP_001261294.1
Coordinates 1202304..1202534 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ67_RS05965 (1199318) 1199318..1201456 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
PTZ67_RS05970 (1201673) 1201673..1202137 + 465 WP_017441190.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PTZ67_RS05975 (1202304) 1202304..1202534 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PTZ67_RS05980 (1202531) 1202531..1202947 + 417 WP_017441191.1 type II toxin-antitoxin system VapC family toxin Toxin
PTZ67_RS05985 (1203008) 1203008..1204921 - 1914 WP_023242878.1 BglG family transcription antiterminator -
PTZ67_RS05990 (1204938) 1204938..1205678 - 741 WP_023229489.1 KDGP aldolase family protein -
PTZ67_RS05995 (1205675) 1205675..1206793 - 1119 WP_001139194.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PTZ67_RS06000 (1206777) 1206777..1207910 - 1134 WP_017441192.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15163.55 Da        Isoelectric Point: 8.1381

>T272370 WP_017441191.1 NZ_CP117851:1202531-1202947 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAVGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT272370 WP_001261294.1 NZ_CP117851:1202304-1202534 [Salmonella enterica subsp. enterica serovar Mbandaka]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References