Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 993222..994845 Replicon chromosome
Accession NZ_CP117851
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_B30R

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag PTZ67_RS04980 Protein ID WP_000088046.1
Coordinates 993520..994845 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag PTZ67_RS04975 Protein ID WP_024136327.1
Coordinates 993222..993515 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ67_RS04940 (988244) 988244..989371 - 1128 WP_014837927.1 DUF3883 domain-containing protein -
PTZ67_RS04945 (989422) 989422..989649 - 228 WP_000248278.1 hypothetical protein -
PTZ67_RS04950 (989673) 989673..989864 + 192 WP_000951934.1 hypothetical protein -
PTZ67_RS04955 (990346) 990346..990888 - 543 WP_000587837.1 AAA family ATPase -
PTZ67_RS04960 (990901) 990901..991761 - 861 WP_000557454.1 aminoglycoside N-acetyltransferase AAC(3)-IId -
PTZ67_RS04965 (991904) 991904..992026 + 123 Protein_967 IS4 family transposase -
PTZ67_RS04970 (992078) 992078..992782 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
PTZ67_RS04975 (993222) 993222..993515 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
PTZ67_RS04980 (993520) 993520..994845 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
PTZ67_RS04985 (994906) 994906..995112 + 207 WP_000134171.1 hypothetical protein -
PTZ67_RS04990 (995214) 995214..995624 + 411 WP_000985911.1 hypothetical protein -
PTZ67_RS04995 (995637) 995637..996452 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
PTZ67_RS05000 (996706) 996706..997131 + 426 WP_001043843.1 hypothetical protein -
PTZ67_RS05005 (997680) 997680..997988 + 309 WP_001224687.1 hypothetical protein -
PTZ67_RS05010 (998004) 998004..998861 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
PTZ67_RS05015 (998923) 998923..999126 + 204 WP_001194555.1 hypothetical protein -
PTZ67_RS05020 (999468) 999468..999824 - 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage sul3 / lnu(F) / ant(3'')-Ia / aac(3)-IId / aph(3')-Ia / blaTEM-1B / blaLAP-2 bcfG / bcfF / bcfE / bcfD / bcfC / bcfB / bcfA 972303..1026879 54576
- inside Prophage sul3 / lnu(F) / ant(3'')-Ia / aac(3)-IId / aph(3')-Ia / blaTEM-1B / blaLAP-2 bcfG / bcfF / bcfE / bcfD / bcfC / bcfB 972303..1016446 44143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T272368 WP_000088046.1 NZ_CP117851:993520-994845 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT272368 WP_024136327.1 NZ_CP117851:993222-993515 [Salmonella enterica subsp. enterica serovar Mbandaka]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References