Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 270268..271082 Replicon chromosome
Accession NZ_CP117851
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_B30R

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3W0Q3Z8
Locus tag PTZ67_RS01375 Protein ID WP_017441137.1
Coordinates 270555..271082 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A418Z520
Locus tag PTZ67_RS01370 Protein ID WP_017441138.1
Coordinates 270268..270558 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ67_RS01340 (266196) 266196..266846 - 651 WP_001728903.1 type III secretion system transcriptional activator InvF -
PTZ67_RS01345 (267302) 267302..267745 + 444 WP_017441140.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PTZ67_RS01350 (268177) 268177..268626 + 450 WP_017441139.1 hypothetical protein -
PTZ67_RS01355 (268611) 268611..268958 + 348 WP_001555786.1 DUF1493 family protein -
PTZ67_RS01360 (269231) 269231..269557 - 327 WP_000393295.1 hypothetical protein -
PTZ67_RS01365 (269798) 269798..269998 + 201 Protein_262 IS3 family transposase -
PTZ67_RS01370 (270268) 270268..270558 + 291 WP_017441138.1 DUF1778 domain-containing protein Antitoxin
PTZ67_RS01375 (270555) 270555..271082 + 528 WP_017441137.1 GNAT family N-acetyltransferase Toxin
PTZ67_RS01380 (271155) 271155..271370 - 216 Protein_265 IS5/IS1182 family transposase -
PTZ67_RS01385 (271708) 271708..272364 + 657 WP_017441135.1 protein-serine/threonine phosphatase -
PTZ67_RS01390 (272535) 272535..273029 - 495 WP_000424947.1 hypothetical protein -
PTZ67_RS01395 (273056) 273056..273724 - 669 WP_000445914.1 hypothetical protein -
PTZ67_RS01400 (273881) 273881..274120 - 240 Protein_269 hypothetical protein -
PTZ67_RS01405 (274311) 274311..274709 - 399 Protein_270 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 271155..271295 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19035.89 Da        Isoelectric Point: 9.6420

>T272363 WP_017441137.1 NZ_CP117851:270555-271082 [Salmonella enterica subsp. enterica serovar Mbandaka]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SLKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10721.55 Da        Isoelectric Point: 8.5957

>AT272363 WP_017441138.1 NZ_CP117851:270268-270558 [Salmonella enterica subsp. enterica serovar Mbandaka]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFARPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W0Q3Z8

Antitoxin

Source ID Structure
AlphaFold DB A0A418Z520

References