Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4391904..4392524 Replicon chromosome
Accession NZ_CP117850
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PTZ65_RS21620 Protein ID WP_001280991.1
Coordinates 4392306..4392524 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PTZ65_RS21615 Protein ID WP_000344807.1
Coordinates 4391904..4392278 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ65_RS21605 (4387043) 4387043..4388236 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PTZ65_RS21610 (4388259) 4388259..4391408 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PTZ65_RS21615 (4391904) 4391904..4392278 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PTZ65_RS21620 (4392306) 4392306..4392524 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PTZ65_RS21625 (4392703) 4392703..4393254 + 552 WP_001278793.1 maltose O-acetyltransferase -
PTZ65_RS21630 (4393370) 4393370..4393840 + 471 WP_000136183.1 YlaC family protein -
PTZ65_RS21635 (4393896) 4393896..4394036 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PTZ65_RS21640 (4394042) 4394042..4394302 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PTZ65_RS21645 (4394527) 4394527..4396077 + 1551 WP_000213140.1 EAL domain-containing protein -
PTZ65_RS21655 (4396308) 4396308..4396697 + 390 WP_000961285.1 MGMT family protein -
PTZ65_RS21660 (4396730) 4396730..4397299 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T272356 WP_001280991.1 NZ_CP117850:4392306-4392524 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT272356 WP_000344807.1 NZ_CP117850:4391904-4392278 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References