272355

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 3350141..3350663 Replicon chromosome
Accession NZ_CP117850
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag PTZ65_RS16380 Protein ID WP_000221345.1
Coordinates 3350379..3350663 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PTZ65_RS16375 Protein ID WP_000885424.1
Coordinates 3350141..3350389 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ65_RS16345 (3345684) 3345684..3346464 + 781 Protein_3182 helix-turn-helix domain-containing protein -
PTZ65_RS16350 (3346466) 3346466..3347374 - 909 WP_077906523.1 hypothetical protein -
PTZ65_RS16355 (3347647) 3347647..3347979 - 333 WP_017441352.1 DUF1493 family protein -
PTZ65_RS16360 (3348502) 3348502..3348618 - 117 Protein_3185 IS110 family transposase -
PTZ65_RS16365 (3348983) 3348983..3349372 + 390 WP_017441353.1 hypothetical protein -
PTZ65_RS16370 (3349375) 3349375..3349728 + 354 WP_000418733.1 hypothetical protein -
PTZ65_RS16375 (3350141) 3350141..3350389 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PTZ65_RS16380 (3350379) 3350379..3350663 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTZ65_RS16385 (3350834) 3350834..3351223 + 390 WP_001652798.1 RidA family protein -
PTZ65_RS16390 (3351281) 3351281..3352354 - 1074 WP_017441355.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PTZ65_RS16395 (3352547) 3352547..3353035 - 489 WP_017441356.1 MarR family winged helix-turn-helix transcriptional regulator -
PTZ65_RS16400 (3353080) 3353080..3354588 + 1509 WP_017441357.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3340935..3357445 16510


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T272355 WP_000221345.1 NZ_CP117850:3350379-3350663 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT272355 WP_000885424.1 NZ_CP117850:3350141-3350389 [Salmonella enterica subsp. enterica serovar Mbandaka]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References