Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1992062..1992876 Replicon chromosome
Accession NZ_CP117850
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3W0Q3Z8
Locus tag PTZ65_RS09745 Protein ID WP_017441137.1
Coordinates 1992062..1992589 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A418Z520
Locus tag PTZ65_RS09750 Protein ID WP_017441138.1
Coordinates 1992586..1992876 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ65_RS09715 (1988435) 1988435..1988833 + 399 Protein_1886 cytoplasmic protein -
PTZ65_RS09720 (1989024) 1989024..1989263 + 240 Protein_1887 hypothetical protein -
PTZ65_RS09725 (1989420) 1989420..1990088 + 669 WP_000445914.1 hypothetical protein -
PTZ65_RS09730 (1990115) 1990115..1990609 + 495 WP_000424947.1 hypothetical protein -
PTZ65_RS09735 (1990780) 1990780..1991436 - 657 WP_017441135.1 protein-serine/threonine phosphatase -
PTZ65_RS09740 (1991774) 1991774..1991989 + 216 Protein_1891 IS5/IS1182 family transposase -
PTZ65_RS09745 (1992062) 1992062..1992589 - 528 WP_017441137.1 GNAT family N-acetyltransferase Toxin
PTZ65_RS09750 (1992586) 1992586..1992876 - 291 WP_017441138.1 DUF1778 domain-containing protein Antitoxin
PTZ65_RS09755 (1993146) 1993146..1993346 - 201 Protein_1894 IS3 family transposase -
PTZ65_RS09760 (1993587) 1993587..1993913 + 327 WP_000393295.1 hypothetical protein -
PTZ65_RS09765 (1994186) 1994186..1994533 - 348 WP_001555786.1 DUF1493 family protein -
PTZ65_RS09770 (1994518) 1994518..1994967 - 450 WP_017441139.1 hypothetical protein -
PTZ65_RS09775 (1995399) 1995399..1995842 - 444 WP_017441140.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PTZ65_RS09780 (1996298) 1996298..1996948 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1991849..2002261 10412
- flank IS/Tn - - 1991849..1991989 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19035.89 Da        Isoelectric Point: 9.6420

>T272349 WP_017441137.1 NZ_CP117850:c1992589-1992062 [Salmonella enterica subsp. enterica serovar Mbandaka]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SLKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10721.55 Da        Isoelectric Point: 8.5957

>AT272349 WP_017441138.1 NZ_CP117850:c1992876-1992586 [Salmonella enterica subsp. enterica serovar Mbandaka]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFARPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W0Q3Z8

Antitoxin

Source ID Structure
AlphaFold DB A0A418Z520

References