Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1310882..1311673 Replicon chromosome
Accession NZ_CP117850
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag PTZ65_RS06410 Protein ID WP_000369560.1
Coordinates 1311155..1311673 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag PTZ65_RS06405 Protein ID WP_001275017.1
Coordinates 1310882..1311151 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ65_RS06385 (1306463) 1306463..1307131 + 669 WP_000617729.1 cell division ATP-binding protein FtsE -
PTZ65_RS06390 (1307124) 1307124..1308179 + 1056 WP_001081707.1 permease-like cell division protein FtsX -
PTZ65_RS06395 (1308425) 1308425..1309279 + 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
PTZ65_RS06400 (1309601) 1309601..1310704 + 1104 WP_001528146.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PTZ65_RS06405 (1310882) 1310882..1311151 + 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
PTZ65_RS06410 (1311155) 1311155..1311673 + 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
PTZ65_RS06415 (1311670) 1311670..1312053 - 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
PTZ65_RS06420 (1312475) 1312475..1313584 + 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PTZ65_RS06425 (1313644) 1313644..1314570 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PTZ65_RS06430 (1314567) 1314567..1315844 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
PTZ65_RS06435 (1315841) 1315841..1316608 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T272345 WP_000369560.1 NZ_CP117850:1311155-1311673 [Salmonella enterica subsp. enterica serovar Mbandaka]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT272345 WP_001275017.1 NZ_CP117850:1310882-1311151 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References