Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 338700..339343 Replicon chromosome
Accession NZ_CP117850
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag PTZ65_RS01785 Protein ID WP_017441191.1
Coordinates 338927..339343 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag PTZ65_RS01780 Protein ID WP_001261294.1
Coordinates 338700..338930 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTZ65_RS01770 (335714) 335714..337852 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
PTZ65_RS01775 (338069) 338069..338533 + 465 WP_017441190.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PTZ65_RS01780 (338700) 338700..338930 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PTZ65_RS01785 (338927) 338927..339343 + 417 WP_017441191.1 type II toxin-antitoxin system VapC family toxin Toxin
PTZ65_RS01790 (339404) 339404..341317 - 1914 WP_023242878.1 BglG family transcription antiterminator -
PTZ65_RS01795 (341334) 341334..342074 - 741 WP_023229489.1 KDGP aldolase family protein -
PTZ65_RS01800 (342071) 342071..343189 - 1119 WP_001139194.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PTZ65_RS01805 (343173) 343173..344306 - 1134 WP_017441192.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15163.55 Da        Isoelectric Point: 8.1381

>T272341 WP_017441191.1 NZ_CP117850:338927-339343 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAVGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT272341 WP_001261294.1 NZ_CP117850:338700-338930 [Salmonella enterica subsp. enterica serovar Mbandaka]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References