Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 129617..131240 | Replicon | chromosome |
| Accession | NZ_CP117850 | ||
| Organism | Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | PTZ65_RS00785 | Protein ID | WP_000088046.1 |
| Coordinates | 129915..131240 (+) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | PTZ65_RS00780 | Protein ID | WP_024136327.1 |
| Coordinates | 129617..129910 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PTZ65_RS00745 (124639) | 124639..125766 | - | 1128 | WP_014837927.1 | DUF3883 domain-containing protein | - |
| PTZ65_RS00750 (125817) | 125817..126044 | - | 228 | WP_000248278.1 | hypothetical protein | - |
| PTZ65_RS00755 (126068) | 126068..126259 | + | 192 | WP_000951934.1 | hypothetical protein | - |
| PTZ65_RS00760 (126741) | 126741..127283 | - | 543 | WP_000587837.1 | AAA family ATPase | - |
| PTZ65_RS00765 (127296) | 127296..128156 | - | 861 | WP_000557454.1 | aminoglycoside N-acetyltransferase AAC(3)-IId | - |
| PTZ65_RS00770 (128299) | 128299..128421 | + | 123 | Protein_153 | IS4 family transposase | - |
| PTZ65_RS00775 (128473) | 128473..129177 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| PTZ65_RS00780 (129617) | 129617..129910 | + | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PTZ65_RS00785 (129915) | 129915..131240 | + | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| PTZ65_RS00790 (131301) | 131301..131507 | + | 207 | WP_000134171.1 | hypothetical protein | - |
| PTZ65_RS00795 (131609) | 131609..132019 | + | 411 | WP_000985911.1 | hypothetical protein | - |
| PTZ65_RS00800 (132032) | 132032..132847 | + | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
| PTZ65_RS00805 (133101) | 133101..133526 | + | 426 | WP_001043843.1 | hypothetical protein | - |
| PTZ65_RS00810 (134075) | 134075..134383 | + | 309 | WP_001224687.1 | hypothetical protein | - |
| PTZ65_RS00815 (134399) | 134399..135256 | + | 858 | WP_000784387.1 | HNH endonuclease signature motif containing protein | - |
| PTZ65_RS00820 (135318) | 135318..135521 | + | 204 | WP_001194555.1 | hypothetical protein | - |
| PTZ65_RS00825 (135863) | 135863..136219 | - | 357 | WP_065311124.1 | H-NS family nucleoid-associated regulatory protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T272339 WP_000088046.1 NZ_CP117850:129915-131240 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT272339 WP_024136327.1 NZ_CP117850:129617-129910 [Salmonella enterica subsp. enterica serovar Mbandaka]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |