Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3811876..3812533 Replicon chromosome
Accession NZ_CP117838
Organism Enterobacter sp. S-33

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag PUP35_RS17985 Protein ID WP_021242050.1
Coordinates 3811876..3812286 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag PUP35_RS17990 Protein ID WP_006178375.1
Coordinates 3812267..3812533 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP35_RS17965 3807869..3809602 - 1734 WP_274240732.1 single-stranded-DNA-specific exonuclease RecJ -
PUP35_RS17970 3809608..3810321 - 714 WP_111963201.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PUP35_RS17975 3810350..3811246 - 897 WP_111963202.1 site-specific tyrosine recombinase XerD -
PUP35_RS17980 3811348..3811869 + 522 WP_008499710.1 flavodoxin FldB -
PUP35_RS17985 3811876..3812286 - 411 WP_021242050.1 protein YgfX Toxin
PUP35_RS17990 3812267..3812533 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
PUP35_RS17995 3812828..3813808 + 981 WP_274240739.1 tRNA-modifying protein YgfZ -
PUP35_RS18000 3813919..3814578 - 660 WP_274240741.1 hemolysin III family protein -
PUP35_RS18005 3814744..3815055 - 312 WP_223582476.1 N(4)-acetylcytidine aminohydrolase -
PUP35_RS18010 3815107..3815838 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
PUP35_RS18015 3815955..3817388 + 1434 WP_274240745.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T272337 WP_021242050.1 NZ_CP117838:c3812286-3811876 [Enterobacter sp. S-33]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT272337 WP_006178375.1 NZ_CP117838:c3812533-3812267 [Enterobacter sp. S-33]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References