Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1659408..1660205 Replicon chromosome
Accession NZ_CP117838
Organism Enterobacter sp. S-33

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag PUP35_RS07765 Protein ID WP_274242535.1
Coordinates 1659684..1660205 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag PUP35_RS07760 Protein ID WP_115874695.1
Coordinates 1659408..1659677 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP35_RS07730 1655034..1655477 - 444 WP_111964502.1 helix-turn-helix domain-containing protein -
PUP35_RS07735 1655630..1656871 + 1242 WP_274242528.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
PUP35_RS07740 1656905..1657132 - 228 WP_008499832.1 YccJ family protein -
PUP35_RS07745 1657153..1657749 - 597 WP_274242531.1 NAD(P)H:quinone oxidoreductase -
PUP35_RS07750 1658141..1658311 + 171 WP_023311077.1 general stress protein -
PUP35_RS07755 1658429..1659346 + 918 WP_115874694.1 DMT family transporter -
PUP35_RS07760 1659408..1659677 + 270 WP_115874695.1 DUF1778 domain-containing protein Antitoxin
PUP35_RS07765 1659684..1660205 + 522 WP_274242535.1 N-acetyltransferase Toxin
PUP35_RS07770 1660279..1661601 - 1323 WP_274242537.1 pyrimidine utilization transport protein G -
PUP35_RS07775 1661623..1662117 - 495 WP_111964498.1 pyrimidine utilization flavin reductase protein F -
PUP35_RS07780 1662127..1662717 - 591 WP_111964497.1 malonic semialdehyde reductase -
PUP35_RS07785 1662727..1663527 - 801 WP_274242542.1 pyrimidine utilization protein D -
PUP35_RS07790 1663535..1663921 - 387 WP_274242544.1 pyrimidine utilization protein C -
PUP35_RS07795 1663933..1664622 - 690 WP_274242545.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19742.51 Da        Isoelectric Point: 7.0497

>T272331 WP_274242535.1 NZ_CP117838:1659684-1660205 [Enterobacter sp. S-33]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDVLNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10279.77 Da        Isoelectric Point: 5.1881

>AT272331 WP_115874695.1 NZ_CP117838:1659408-1659677 [Enterobacter sp. S-33]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIENPPEPNERLMR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References