Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1073539..1074159 Replicon chromosome
Accession NZ_CP117838
Organism Enterobacter sp. S-33

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag PUP35_RS04990 Protein ID WP_008499287.1
Coordinates 1073539..1073757 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag PUP35_RS04995 Protein ID WP_008499288.1
Coordinates 1073785..1074159 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP35_RS04960 1069554..1069814 + 261 WP_274242237.1 type B 50S ribosomal protein L31 -
PUP35_RS04965 1069817..1069957 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PUP35_RS04970 1069954..1070664 - 711 WP_133293898.1 GNAT family protein -
PUP35_RS04975 1070766..1072226 + 1461 WP_274242238.1 PLP-dependent aminotransferase family protein -
PUP35_RS04980 1072198..1072665 - 468 WP_023310598.1 YlaC family protein -
PUP35_RS04985 1072783..1073334 - 552 WP_023310599.1 maltose O-acetyltransferase -
PUP35_RS04990 1073539..1073757 - 219 WP_008499287.1 HHA domain-containing protein Toxin
PUP35_RS04995 1073785..1074159 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
PUP35_RS05000 1074670..1077816 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit AcrB -
PUP35_RS05005 1077839..1079032 - 1194 WP_115874373.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T272329 WP_008499287.1 NZ_CP117838:c1073757-1073539 [Enterobacter sp. S-33]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT272329 WP_008499288.1 NZ_CP117838:c1074159-1073785 [Enterobacter sp. S-33]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References