Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2321949..2322463 Replicon chromosome
Accession NZ_CP117825
Organism Fusobacterium nucleatum strain FNP

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag PSC67_RS11590 Protein ID WP_098978559.1
Coordinates 2321949..2322206 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U7TQU0
Locus tag PSC67_RS11595 Protein ID WP_005919458.1
Coordinates 2322206..2322463 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSC67_RS11570 (PSC67_11570) 2318107..2318739 - 633 WP_271332831.1 hypothetical protein -
PSC67_RS11575 (PSC67_11575) 2319031..2319888 - 858 WP_271332832.1 toxin-antitoxin system YwqK family antitoxin -
PSC67_RS11580 (PSC67_11580) 2320010..2320747 - 738 WP_088389324.1 tRNA pseudouridine(38-40) synthase TruA -
PSC67_RS11585 (PSC67_11585) 2320756..2321832 - 1077 WP_271332834.1 DHH family phosphoesterase -
PSC67_RS11590 (PSC67_11590) 2321949..2322206 - 258 WP_098978559.1 Txe/YoeB family addiction module toxin Toxin
PSC67_RS11595 (PSC67_11595) 2322206..2322463 - 258 WP_005919458.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PSC67_RS11600 (PSC67_11600) 2322583..2322729 - 147 Protein_2268 glycerophosphodiester phosphodiesterase -
PSC67_RS11605 (PSC67_11605) 2322731..2323729 - 999 WP_274180167.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
PSC67_RS11610 (PSC67_11610) 2323755..2324228 - 474 WP_005894577.1 OmpH family outer membrane protein -
PSC67_RS11615 (PSC67_11615) 2324268..2326361 - 2094 WP_274180168.1 outer membrane protein assembly factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10144.74 Da        Isoelectric Point: 9.7287

>T272325 WP_098978559.1 NZ_CP117825:c2322206-2321949 [Fusobacterium nucleatum]
MLLTWTDFAWKQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDSQIIIVAC
ANHYK

Download         Length: 258 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10110.43 Da        Isoelectric Point: 4.7022

>AT272325 WP_005919458.1 NZ_CP117825:c2322463-2322206 [Fusobacterium nucleatum]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2ZLE4

References